csaA [2017-07-24 09:46:47]

molecular chaperone involved in protein secretion

locus: BSU19040

pI: 8.69

mw: 11.77 kDa

protein length: 110 aa

gene length: 330 bp

function: protein secretion

product: molecular chaperone

essential: no

synonyms

Genomic Context

categories

• [category|SW 3|Information processing] → [category|SW 3.3|Protein synthesis, modification and degradation] → [category|SW 3.3.5|Protein secretion]

Gene

Coordinates: 2,079,214 → 2,079,546

Phenotypes of a mutant

• From unsuccessful trials to knock out the gene it was concluded that ''csaA'' apparently is essential. However, in a conditional mutant (Pspac-''csaA''), depletion of the gene product is not lethal. But secretion of some proteins including [protein|820635420B3980B620F3E3D7ACF7EDE9DC6275AD|SdpC] was reported to be affected unter such conditions.[Pubmed|10816431]

The protein

Catalyzed reaction/ biological activity

• Secretion associated chaperone. Assumed functional analogue of ''E. coli'' SecB

Protein family

• FIG1 subfamily (according to Swiss-Prot)

[SW|Domains]

• CsaA contains a tRNA binding domain.

Structure

• [PDB|2NZO]

[SW|Localization]

• cell membrane (according to Swiss-Prot)

Additional information

• The functional entity of CsaA is the homodimer.

Expression and Regulation

Operons

• genes: [gene|EDD0C5732E487A7F94684289F59B9130773316C1|yobT]-[gene|BB122C73972ACEA08DE97F95FC9AC249671C86A3|yobS]-[gene|6D9AAA63C4E43D2F80C7A2104BDF4D98A21C3B78|yobR]-[gene|6C67AD722D59671ED7589949690773732A8B845F|yobQ]-[gene|DA4A64BDF322EDE9EECE83AC9D4AAA01D3F16720|csaA]
  description: [pubmed|22383849]

• genes: [gene|6D9AAA63C4E43D2F80C7A2104BDF4D98A21C3B78|yobR]-[gene|6C67AD722D59671ED7589949690773732A8B845F|yobQ]-[gene|DA4A64BDF322EDE9EECE83AC9D4AAA01D3F16720|csaA]
  description: [pubmed|22383849]

Biological materials

Mutant

• Pspac-csaA [Pubmed|10816431]

References

Reviews

• 25212246

Original publications

• 10816431,13129613,17372352,10658654